UniVax publications 

Linear, Star, and Comb Oxidation-Responsive Polymers: Effect of Branching Degree and Topology on Aggregation and Responsiveness
Richard d'Arcy, Arianna Gennari, Roberto Donno, Nicola Tirelli
Macromolecular Rapid Communications; Vol. 37/Issue 23, 2016; Wiley-VCH Verlag; 10.1002/marc.201600481

Chitosan/Hyaluronic Acid Nanoparticles: Rational Design Revisited for RNA Delivery
Enrique Lallana, Julio M. Rios de la Rosa, Annalisa Tirella, Maria Pelliccia, Arianna Gennari, Ian J. Stratford, Sanyogitta Puri, Marianne Ashford, Nicola Tirelli
Molecular Pharmaceutics, Vol. 14/Issue 7, American Chemical Society, 2017; 10.1021/acs.molpharmaceut.7b00320

 The CD44-Mediated Uptake of Hyaluronic Acid-Based Carriers in Macrophages
Julio M. Rios de la Rosa, Annalisa Tirella, Arianna Gennari, Ian J. Stratford, Nicola Tirelli        
Advanced Healthcare Materials, Vol. 6/Issue 4, WILEY-VCH Verlag GmbH & Co, 2017; 10.1002/adhm.201601012

Revisiting Boronate/Diol Complexation as a Double Stimulus-Responsive Bioconjugation
Arianna Gennari, Chirag Gujral, Erwin Hohn, Enrique Lallana, Francesco Cellesi, Nicola Tirelli                
Bioconjugate Chemistry, Vol. 28/Issue 5, American Chemical Society, 2017; 10.1021/acs.bioconjchem.7b00080

Impact of pre-existing immunity on the induction of functional cross-reactive anti-hemagglutinin stalk antibodies following vaccination with an AS03 adjuvanted pandemic H1N1 vaccine
Tete SM, Jul-Larsen Å, Rostami S, Felli Lunde TH, Søland H, Krammer F, Cox RJ.
Vaccine 2018 018 Apr 12;36(16):2213-2219; DOI:10.1016/j.vaccine.2018.02.022

Immune responses after live attenuated influenza vaccination
Mohn KG, Smith I, Sjursen H, Cox RJ.
Hum Vaccin Immunother. 2018 Mar 4;14(3):571-578; DOI:10.1080/21645515.2017.1377376

Antibody response to seasonal influenza vaccination in multiple sclerosis patients receiving immunomodulatory therapy
Olberg H, Eide G, Cox RJ, Jul-Larsen, Å, Lartey S, Vedeler C, Myhr KM.
European Journal of Neurology 
2018 Mar;25(3):527-534; DOI:10.1111/ene.13537

Distinct T and NK cell populations may serve as immune correlates of protection against symptomatic pandemic influenza A(H1N1) virus infection during pregnancy
Savic M, Dembinski JL, Laake I, Hungnes O, Cox RJ, Oftung F, Trogstad L, Mjaaland S
PLOS ONE 2017  12(11): e0188055. doi.org/10.1371/journal.pone.0188055

A DNA Vaccine That Targets Hemagglutinin to Antigen-Presenting Cells Protects Mice against H7 Influenza
Andersen TK,  Zhou F, Cox R, Bogen B, Grødeland G
December 2017 Volume 91 Issue 23 e01340-17; DOI:10.1128/JVI.01340-17

High prevalence of humoral and cellular immunity to influenza viruses in pre-school children living in Addis Ababa, Ethiopia
Dembinski JL, Mihret A,. Yimer SA, Tessema B , Trieu MC, Tarekegn A, Getachew N, Cox RJ, Oftung F, Haneberg B, Aseffa A,  Mjaaland S .
Open Forum Infect Dis. 2017 Feb 11;4(1):ofx026. doi: 10.1093/ofid/ofx026. 

Mucosal Administration of Cycle-Di-Nucleotide-Adjuvanted Virosomes Efficiently Induces Protection against Influenza H5N1 in Mice
Ebensen T, Debarry J, Pedersen GK, Blazejewska P, Weissmann S, Schulze K, McCullough KC, Cox RJ, Guzmán CA.
Front Immunol. 2017 Sep 28;8:1223; DOI:10.3389/fimmu.2017.01223 

Influenza Virus Hemagglutinin Stalk-Specific Antibodies in Human Serum are a Surrogate Marker for In Vivo Protection in a Serum Transfer Mouse Challenge Model.
Jacobsen H, Rajendran M, Choi A, Sjursen H, Brokstad KA, Cox RJ, Palese P, Krammer F, Nachbagauer R.
MBio. 2017 Sep 19;8(5). pii: e01463-17. DOI:10.1128/mBio.01463-17

Boosting of Cross-Reactive and Protection-Associated T Cells in Children After Live attenuated influenza vaccination in children.   
ohn KG, Zhou F, Brokstad KA, Sridhar S, Cox RJ. 
J Infect Dis. 2017 Mar 27. doi: 10.1093/infdis/jix165

Influenza A haemagglutinin specific IgG responses in children and adults after seasonal trivalent live attenuated influenza vaccination.
Islam S, Mohn KG, Krammer F, Sanne M, Bredholt G, Jul-Larsen , Tete SM, Zhou F, Brokstad KA, Cox RJ.
Vaccine. 2017 Oct 9;35(42):5666-567; DOI:10.1016/j.vaccine.2017.08.044 

Long-term maintenance of the influenza-specific cross-reactive memory CD4+ T-cell responses following repeated annual influenza vaccination.
Trieu MC, Zhou F, Lartey S, Jul-Larsen Å, Mjaaland S, Sridhar S, Cox RJ.
J Infect Dis (2017) 215 (5): 740-749; DOI:10.1093/infdis/jiw619

Self-replicating RNA vaccine functionality modulated by fine-tuning of polyplex delivery vehicle structure
Démoulins T, Ebensen T, Schulze K, Englezou PC, Pelliccia M, Guzmán CA, Ruggli N, McCullough KC
J Control Release 2017 Nov 28;266:256-271; DOI:10.1016/j.jconrel.2017.09.018


Self-Replicating RNA Vaccine Delivery to Dendritic Cells
Démoulins T, Englezou PC, Milona P, Ruggli N, Tirelli N, Pichon C, Sapet C, Ebensen T, Guzmán CA, McCullough KC
Methods Mol Biol 2017;1499:37-75; DOI:10.1007/978-1-4939-6481-9_3


Polyethylenimine-based polyplex delivery of self-replicating RNA vaccines
Démoulins T, Milona P, Englezou PC, Ebensen T, Schulze K, Suter R, Pichon C, Midoux P, Guzmán CA, Ruggli N, McCullough KC.
Nanomedicine 2016 Apr;12(3):711-722.; DOI: 10.1016/j.nano.2015.11.001





Induction of Broadly Reactive Anti-Hemagglutinin Stalk Antibodies by an H5N1 Vaccine in Humans
R. Nachbagauer , T. J. Wohlbold , A. Hirsh , R. Hai , H. Sjursen , P. Palese , R. J. Cox , F. Krammer
D.O.I. 10.1128/JVI.02133-14  Journal of Virology

Dissecting the hemagglutinin head and stalk-specific IgG antibody response in healthcare workers following pandemic H1N1 vaccination
Sarah M Tete , Florian Krammer , Sarah Lartey , Geir Bredholt , John Wood , Steinar Skrede, Rebecca J Cox
D.O.I.  10.1038/npjvaccines.2016.1     Nature

Humoral, T-cell and B-cell immune responses to seasonal influenza vaccine in solid organ transplant recipients receiving anti-T cell therapies
Delphine Héquet , Manuel Pascual , Sarah Lartey , Rishi D. Pathirana , Geir Bredholt , Katja Hoschler , Roger Hullin , Pascal Meylan , Rebecca J. Cox , Oriol Manuel
10.1016/j.vaccine.2016.05.021    Vaccine

Influence of Primary Structure on Responsiveness. Oxidative, Thermal, and Thermo-Oxidative Responses in Polysulfides
Richard d’Arcy  Alessandro Siani  Enrique Lallana  and Nicola Tirelli
Macromolecules, 2015, 48 (22), pp 8108–8120
DOI: 10.1021/acs.macromol.5b02007

Hyaluronan/Tannic Acid Nanoparticles Via Catechol/Boronate Complexation as a Smart Antibacterial System
Elita Montanari, Arianna Gennari, Maria Pelliccia, Charlotte Gourmel, Enrique Lallana,
Pietro Matricardi, Andrew J. McBain, Nicola Tirelli
DOI: 10.1002/mabi.201600311  Macromolecular Bioscience

Mannosylation Allows for Synergic (CD44/C-Type Lectin) Uptake of Hyaluronic Acid Nanoparticles in Dendritic Cells, but Only upon Correct Ligand Presentation
Arianna Gennari, Maria Pelliccia, Roberto Donno, Ian Kimber, Nicola Tirelli
DOI: 10.1002/adhm.201500941 Advanced Healthcare Materials

Dendritic Cell Targets for Self-Replicating RNA Vaccines
Kenneth C. McCullough, Panagiota Milona, Thomas Démoulins, Pavlos Englezou, Nicolas Ruggli
Blood, 2015

Self-replicating Replicon-RNA Delivery to Dendritic Cells by Chitosan-nanoparticles for Translation In Vitro and In Vivo
McCullough KC, Bassi I, Milona P, Suter R, Thomann-Harwood L, Englezou P, Démoulins T, Ruggli N.
Molecular Therapy, 2014

Alginate-coated chitosan nanogels differentially modulate class-A and class-B CpG-ODN targeting of dendritic cells and intracellular delivery
Démoulins T, Milona P, McCullough KC.
Nanomedicine: Nanotechnology, Biology, and Medicine, 2014

Intranasal formulations: promising strategy to deliver vaccines
Peggy Riese , Priya Sakthivel , Stephanie Trittel , Carlos A Guzmán
Expert Opinion on Drug Delivery, Vol. 11/Issue 10, 2014

Self-Amplifying Replicon RNA Vaccine Delivery to Dendritic Cells by Synthetic Nanoparticles
McCullough KC, Milona P, Thomann-Harwood L, Démoulins T, Englezou P, Suter R, Ruggli N.
Open Vaccine Journal, 2014 



Further dissemination activities

Conference sessions

Messenger RNA therapeutics: advances and perspectives, March 2017, Orléans 



Hyaluronan/tannic acid nanoparticles via catechol/boronate complexation
AFPM2016  Advanced Functional Polymers for Medicine, University of Twente (The Netherlands)
By Uni Manchester

Tyrosinase-mediated bioconjugation: clicking a tag-peptide to hyaluronan
30th Conference of the European Colloid and Interface Society (ECIS2016), University Sapienza, Rome
By Uni Manchester

Hyaluronan/tannic acid nanoparticles via catechol/boronate complexation
NowCADD International workshop, Frontiers in drug delivery: Biological targets and advanced nano carriers
By Uni Manchester

Hyaluronic Acid-Coated Chitosan Nanoparticles: the Influence of Hyaluronic Acid Presentation
26th Annual Conference of the European Society for Biomaterials (ESB). Liverpool, UK



Hyaluronic Acid-Coated Chitosan Nanoparticles: the Influence of Hyaluronic Acid Presentation
International Conference on Biomaterials, Bioengineering and Biodiagnostics. Delhi, India.
By University of Manchester

Histidylated nanoparticles for mRNA vaccines delivery
World Vaccine congress Europe 2014, Brussels


Lipid-based mRNA vaccine delivery systems
Expert Rev. Vaccines, 1-14 (2014)